Advances in the management of generalized convulsive status epilepticus: what have we learned?

Abstract Convulsive status epilepticus is the most serious manifestation of an epileptic diathesis. In early stages (5–30 min), there exists class A evidence to support efficacy benzodiazepines as first-line treatment. As progresses into later stages, for treatment becomes less robust until we are depending upon short case series and reports refractory epilepticus. However, past year saw publication three randomized controlled trials in setting benzodiazepine-resistant established convulsive epilepticus: EcLiPSE ConSEPT studies, compared levetiracetam phenytoin children; ESETT study fosphenytoin, sodium valproate adults children. addition, emergence data from SENSE study, a multicentre multinational prospective cohort systematic review meta-analysis mortality over 30 years, has brought sharp focus. this update provide detailed analysis these studies their impact on clinical practice. We contentious areas management where consensus lacking advance more research existing alternative strategies.